The Drug-Induced Respiratory Disease Website

Anaphylaxis - Anaphylactoid reaction (either of these can be fatal)

Can be near-fatal or fatal (PMID 19210362)

Wu BL, He WX, Ke M, Shang-Guan XF, He GF, Huang R

A Retrospective Analysis on 1330 Adverse Event Reports of Qingkailing in China: Further Perception of Its Risks and Rational Use.

Current medical science 2018 Dec;38;1103-1108 — 2018 Dec — 1103-1108

Zhan Q

Literature analysis of Acanthopanax anaphylactic shock in China.

Journal of traditional and complementary medicine 2015 Oct;5;253-7 — 2015 Oct — 253-7

Ji K, Chen J, Li M, Liu Z, Xia L, Wang C, Zhan Z, Wu X

Comments on serious anaphylaxis caused by nine Chinese herbal injections used to treat common colds and upper respiratory tract infections.

Regulatory toxicology and pharmacology : RTP 2009 Nov;55;134-8 — 2009 Nov — 134-8

Ji KM, Li M, Chen JJ, Zhan ZK, Liu ZG

Anaphylactic shock and lethal anaphylaxis caused by Houttuynia Cordata injection, a herbal treatment in China.

Allergy 2009 May;64;816-7 — 2009 May — 816-7

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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