The Drug-Induced Respiratory Disease Website

Propofol

Cardiovascular collapse - Cardiogenic shock - Hypotension

See also under Xf and XIIe, , f, g, k, l, o, s, t, ad, ag

Karan A, Maaliki N, Kogler WM, Esmail K

Acute Decompensated Heart Failure and Cardiogenic Shock Following Propofol Infusion: A Report and Review of Pathophysiology.

Cureus 2023 Jul;15;e41815 — 2023 Jul — e41815

Christensen RE, Nause-Osthoff RC, Waldman JC, Spratt DE, Hearn JWD

Adverse events in radiation oncology: A case series from wake up safe, the pediatric anesthesia quality improvement initiative.

Paediatric anaesthesia 2019 Mar;29;265-270 — 2019 Mar — 265-270

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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