The Drug-Induced Respiratory Disease Website

Clozapine

Path: Eosinophilic myocarditis

See under XIIh

Rhee DW, Diuguid-Gerber J, Kondracke A

Five Cases of Clozapine-Associated Cardiotoxicity and Implications for Monitoring.

Psychosomatics 2018 Nov 24;; — 2018 Nov 24

Pieroni M, Cavallaro R, Chimenti C, Smeraldi E, Frustaci A

Clozapine-induced hypersensitivity myocarditis.

Chest 2004 Nov;126;1703-5 — 2004 Nov — 1703-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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