The Drug-Induced Respiratory Disease Website

Aspirin (Salicylate-ASA) - Aspirin containing drugs

Path: Pulmonary edema

Bland alveolar edema/flooding. Typical pulmonary edema is acute alveolar flooding with pulmonary congestion but little or no interstitial changes otherwise. Pulmonary edema may accompany severe NSIP and granulomatous ILD. See also II/IIa

Publications

Gonzolez ER, Cole T, Grimes MM, Fink RA, Fowler AA

Recurrent ARDS in a 39-year-old woman with migraine headaches.

Chest 1998 Sep;114;919-22 — 1998 Sep — 919-22

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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