The Drug-Induced Respiratory Disease Website
Pleural effusion (uni or bilateral) (can accompany ILD induced by the drug)
Evidence level
low
Lone, isolated, free-flowing pleural effusion on imaging. See other forms of pleural effusions under Vb, d, e, g, h, i, m which may present similarly on imaging. The effusion can be uni- or bilateral. More often a lymphocyte-, mixed or neutrophil-rich exudate. At times the effusion is eosipophil-rich. Pleural effusion can be present with the acute clinical phase of severe drug-induced ILD (e.g. methotrexate lung; PMID 16840219). In general, pleural effusion in the context of drug-induced ILD or pulmonary edema is not tabulated under this heading. ANA-panel indicated to diagnose drug-induced lupus PMID 10424528
Publications
The burden of managing pleural effusions in patients with chronic myelogenous leukemia post-imatinib failure: A literature-based economic analysis.
International journal of general medicine 2010 Apr 08;3;31-6 — 2010 Apr 08 — 31-6
Prominent pleural effusion possibly due to imatinib mesylate in adult Philadelphia chromosome-positive acute lymphoblastic leukemia.
Internal medicine (Tokyo, Japan) 2006;45;339-40 — 2006 — 339-40
Pleural-pericardic effusion as uncommon complication in CML patients treated with Imatinib.
European journal of haematology 2005 Jan;74;89-90 — 2005 Jan — 89-90
Unexpected pleural effusions in 3 pediatric patients treated with STI-571.
Journal of pediatric hematology/oncology 2002 Nov;24;694-5 — 2002 Nov — 694-5