The Drug-Induced Respiratory Disease Website

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

Pulmonary edema, cardiogenic

(Fr: OAP cardiogénique). Can result from left or biventricular dysfunction/failure. See also under XIIa, XIId, XIIai

Publications

Gallegos C, Rottmann D, Nguyen VQ, Baldassarre LA

Myocarditis with checkpoint inhibitor immunotherapy: case report of late gadolinium enhancement on cardiac magnetic resonance with pathology correlate.

European heart journal. Case reports 2019 Mar;3;yty149 — 2019 Mar — yty149

Matson DR, Accola MA, Rehrauer WM, Corliss RF

Fatal Myocarditis Following Treatment with the PD-1 Inhibitor Nivolumab.

Journal of forensic sciences 2018 May;63;954-957 — 2018 May — 954-957

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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