The Drug-Induced Respiratory Disease Website

Doxorubicin - Adriamycin

Endocardial fibroelastosis

Polverino W, Basso A, Genovese A, De Alfieri W, Latte S, Cacciapuoti AA, Carone T

[Complete left branch block during treatment with adriamycin. Description of a clinical case].

Minerva cardioangiologica 1980 Jun;28;457-62 — 1980 Jun — 457-62

Conroy B, Guthrie W

Endocardial fibroelastosis associated with fatal adriamycin (doxorubicin) cardiomyopathy during treatment of Ewing's sarcoma.

Scottish medical journal 1983 Jul;28;295-9 — 1983 Jul — 295-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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