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Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

Pericardial effusion (w/wo tamponade)

Pericarditis (i.e. pericardial inflammation) is usually heralded by acute mediothoracic chest pain (PMID 10878205). Large effusions can be ANA positive and cause pericardial tamponade. When present as a longterm sequela, pericardial thickening may cause restriction and constriction. See also under Vc, d, g, m and XIIk (PMID 20511488, 23376916)

Publications

Mascolo A, Scavone C, Ferrajolo C, Rafaniello C, Danesi R, Del Re M, Russo A, Coscioni E, Rossi F, Alfano R, Capuano A

Immune Checkpoint Inhibitors and Cardiotoxicity: An Analysis of Spontaneous Reports in Eudravigilance.

Drug safety 2021 Jun 18;; — 2021 Jun 18

Inno A, Maurea N, Metro G, Carbone A, Russo A, Gori S

Immune checkpoint inhibitors-associated pericardial disease: a systematic review of case reports.

Cancer immunology, immunotherapy : CII 2021 Oct;70;3041-3053 — 2021 Oct — 3041-3053

Altan M, Toki MI, Gettinger SN, Carvajal-Hausdorf DE, Zugazagoitia J, Sinard JH, Herbst RS, Rimm DL

Immune Checkpoint Inhibitor-Associated Pericarditis.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2019 Jun;14;1102-1108 — 2019 Jun — 1102-1108

Atallah-Yunes SA, Kadado AJ, Soe MH

Pericardial effusion due to pembrolizumab-induced immunotoxicity: A case report and literature review.

Current problems in cancer 2019 Jan 18;; — 2019 Jan 18

Salem JE, Manouchehri A, Moey M, Lebrun-Vignes B, Bastarache L, Pariente A, Gobert A, Spano JP, Balko JM, Bonaca MP, Roden DM, Johnson DB, Moslehi JJ

Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study.

The Lancet. Oncology 2018 12;19;1579-1589 — 2018 12 — 1579-1589

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