The Drug-Induced Respiratory Disease Website

Aminopyridine

Pulmonary arterial hypertension

May reverse with drug discontinuation. Generally similar to primary PHTn clinically, hemodynamically and on pathology. PMID 23997051. A few cases are thromboembolic in nature (PMID 24881082). Reviews at PMID 29508628, 30545968

Publications

Antigny F, Chaumais MC, Humbert M, Montani D

Pulmonary arterial hypertension in patient treated for multiple sclerosis with 4-aminopyridine.

Fundamental & clinical pharmacology 2019 Aug;33;426-427 — 2019 Aug — 426-427

Ribeiro Baptista B, Petitpain N, Gomez E, Yelehé-Okouma M, Valentin S, Guillaumot A, Chabot F, Chaouat A

Pulmonary arterial hypertension in patient treated for multiple sclerosis with 4-aminopyridine.

Fundamental & clinical pharmacology 2019 Feb;33;127-129 — 2019 Feb — 127-129

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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