The Drug-Induced Respiratory Disease Website

IVDU - IVDA

Endocarditis (infective)

Typically right-sided. Can be bacterial or mycotic. The possibility of systemic septic embolism should be investigated

Shain LM, Ahmed T, Bodine ML, Bauman JG

Drug use-related right-sided infective endocarditis complicated by empyema and bronchopleural fistula.

BMJ case reports 2022 Jan 13;15; — 2022 Jan 13

Riangwiwat T, Dworkin J

Tricuspid Valve Infective Endocarditis Due to in Intravenous Drug User.

Hawai'i journal of medicine & public health : a journal of Asia Pacific Medicine & Public Health 2019 Mar;78;98-102 — 2019 Mar — 98-102

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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