The Drug-Induced Respiratory Disease Website

Loperamide

Bradycardia

Palkar P, Kothari D

Bradycardia and Syncope in a Patient Presenting With Loperamide Abuse.

Cureus 2018 May 09;10;e2599 — 2018 May 09 — e2599

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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