The Drug-Induced Respiratory Disease Website

Veterinary: Cardiotoxicity

Crowley JD, Thomas KA, Donahoe SL, Child G, Hickey MC, Mooney ET

Hypoventilation, cardiac dysrhythmia, and cardiac arrest following acute Brunfelsia species (Yesterday, today, tomorrow) intoxication in a dog.

Australian veterinary journal 2019 Jun;97;202-207 — 2019 Jun — 202-207

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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