The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Pharmacovigilance Analysis of Serious Adverse Events Reported for Biologic Response Modifiers Used as Prophylaxis against Transplant Rejection: a Real-World Postmarketing Experience from the US FDA Adverse Event Reporting System (FAERS).
International journal of organ transplantation medicine 2013;4;62-71 — 2013 — 62-71
Antithymocyte globulin-induced acute respiratory distress syndrome after renal transplantation: a case report.
Chinese medical journal 2012 May;125;1664-6 — 2012 May — 1664-6
Anti-thymocyte globulin induced non-cardiogenic pulmonary edema during renal transplantation.
Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine 2011 Oct;15;230-2 — 2011 Oct — 230-2
Acute lung injury during antithymocyte globulin therapy for aplastic anemia.
Canadian respiratory journal 2009 Mar-Apr;16;e3-5 — 2009 Mar-Apr — e3-5
Transient pulmonary infiltrates during treatment with anti-thymocyte globulin.
Respiration; international review of thoracic diseases 1999;66;279-82 — 1999 — 279-82