The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
A case of recurrent chronic eosinophilic pneumonia after switching from benralizumab to dupilumab.
Respiratory medicine case reports 2024;47;101968 — 2024 — 101968
Eosinophilic pneumonia developed after dupilumab administration in a patient with atopic dermatitis.
Respirology case reports 2023 Aug;11;e01192 — 2023 Aug — e01192
A case of chronic eosinophilic pneumonia in a patient treated with dupilumab.
Therapeutics and clinical risk management 2019;15;869-875 — 2019 — 869-875