The Drug-Induced Respiratory Disease Website

Obliterative bronchiolitis (an imaging and/or pathological pattern consistent with)

In the case described (PMID 27144798), underlying ulcerative colitis, and/or therapy with mesalazine may have played a role

O'Beirne SL, Legasto AC, Narula N, Gelbman BD

Trust Your Instincts. Surgical Lung Biopsy with Normal Chest Imaging in a 49-Year-Old Man with Progressive Dyspnea.

Annals of the American Thoracic Society 2016 05;13;741-5 — 2016 05 — 741-5

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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