The Drug-Induced Respiratory Disease Website

Durvalumab

Imaging: Centrilobular micronodules (can be diffuse)

Domblides M, Geier M, Decroisette C, Descourt R

Durvalumab-induced lesions of bronchiolitis and fully reversible bronchiectasis in a patient with non-small cell lung cancer: A case report.

Thoracic cancer 2021 04;12;1240-1243 — 2021 04 — 1240-1243

Yamasaki M, Taniwaki M, Kawamoto K, Matsumoto N, Hashimoto K, Nabeshima S, Ohashi N, Hattori N

Durvalumab-Induced Organizing Pneumonia with a Diffuse Micronodular Pattern in a Lung Cancer Patient.

American journal of respiratory and critical care medicine 2019 Nov 11;; — 2019 Nov 11

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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