The Drug-Induced Respiratory Disease Website
(Fr: bronchospasme, asthme). Including bronchospasm, bronchoconstriction, de novo subacute asthma, asthma attack and deterioration or exacerbation of preexisting/underlying asthma. Can be sudden and very severe, causing asphyxia followed by irreversible hypoxic brain damage (see also under IVf). NSAIDs, ß-blockers and antibiotics are the main causal agents. Patients with a background of atopy or asthma are particularly at risk. In a few individuals, the asthma may persist despite cessation of exposure (PMID 45308). Healthcare workers can be involved when handling drugs (PMID 3612323). Workers in the drug-manufacturing (e.g. antibiotics) industry can develop bronchospasm or asthma as a manifestation of drug-induced occupational disease (PMID 16436155, 21603168, 30075340)
Publications
Chronic cough and an atypical pattern of peripheral pulmonary opacities: A case report secondary to suspected drug onset.
The Journal of asthma : official journal of the Association for the Care of Asthma 2018 01;55;106-110 — 2018 01 — 106-110
Asthma-like symptoms in a patient with rheumatoid arthritis and Adalimumab treatment.
Pneumologia (Bucharest, Romania) 2015 Oct-Dec;64;28-30 — 2015 Oct-Dec — 28-30
Asthma unmasked with tumor necrosis factor-?-blocking drugs.
Chest 2011 Oct;140;1068-1071 — 2011 Oct — 1068-1071
Bronchospasm associated with anti-TNF treatment.
Clinical rheumatology 2009 Aug;28;989-92 — 2009 Aug — 989-92
Adalimumab-induced bronchospasm: not a class effect.
Thorax 2008 May;63;472-3 — 2008 May — 472-3