The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
Daptomycin and acute lung injury: recognising drug-induced eosinophilic pneumonia.
BMJ case reports 2025 Jul 18;18; — 2025 Jul 18
A Diagnostic Dilemma: Daptomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Eosinophilic Pneumonia With Concurrent COVID-19.
Cureus 2025 Jan;17;e77736 — 2025 Jan — e77736
Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L
Daptomycin-induced eosinophilic pneumonia: a case report and systematic review.
Chemotherapy 2023 Nov 14;; — 2023 Nov 14
Daptomycin-Induced Pulmonary Toxicity: A Case Series.
Cureus 2023 May;15;e39613 — 2023 May — e39613
Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm.
Open forum infectious diseases 2022 Nov;9;ofac577 — 2022 Nov — ofac577
Daptomycin-Induced Eosinophilic Pneumonia Mimicking Multifocal Pneumonia.
Cureus 2022 Oct;14;e30521 — 2022 Oct — e30521
Eosinophilic Syndromes Associated With Daptomycin Use: Re-exposure Hypersensitivity Pneumonitis and Prior Peripheral Eosinophilia.
Open forum infectious diseases 2022 Apr;9;ofac065 — 2022 Apr — ofac065
Acute Eosinophilic Pneumonia Secondary to Daptomycin.
Cureus 2021 Nov;13;e19403 — 2021 Nov — e19403
Multifocal Pneumonia Amidst the Global COVID-19 Pandemic: A Case of Daptomycin-Induced Eosinophilic Pneumonia.
Cureus 2021 Jun;13;e16002 — 2021 Jun — e16002
Daptomycin-induced eosinophilic pneumonia: Are there any risk factors?
Infectious diseases now 2021 Jan 09;; — 2021 Jan 09
Daptomycin-Induced Acute Eosinophilic Pneumonia.
Cureus 2021 Feb 23;13;e13509 — 2021 Feb 23 — e13509
Unexpected Outcome of Daptomycin-induced Eosinophilic Pneumonia: Rarity Within a Rarity.
Cureus 2019 Dec 02;11;e6271 — 2019 Dec 02 — e6271
Daptomycin associated eosinophilic pneumonia: case report and differential diagnoses.
Journal of community hospital internal medicine perspectives 2018;8;152-155 — 2018 — 152-155
Drug-induced eosinophilic pneumonia: A review of 196 case reports.
Medicine 2018 Jan;97;e9688 — 2018 Jan — e9688
Higashi Y, Nakamura S, Tsuji Y, Ogami C, Matsumoto K, Kawago K, Tokui K, Hayashi R, Sakamaki I, Yamamoto Y
Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature.
Internal medicine (Tokyo, Japan) 2018 Jan 15;57;253-258 — 2018 Jan 15 — 253-258
Hirai J, Hagihara M, Haranaga S, Kinjo T, Hashioka H, Kato H, Sakanashi D, Yamagishi Y, Mikamo H, Fujita J
Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions and a review of the literature.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2017 Apr;23;245-249 — 2017 Apr — 245-249
Daptomycin-induced eosinophilic pneumonia - a systematic review.
Antimicrobial resistance and infection control 2016;5;55 — 2016 — 55
Durante-Mangoni E, Andini R, Parrella A, Mattucci I, Cavezza G, Senese A, Trojaniello C, Caprioli R, Diana MV, Utili R
Safety of treatment with high-dose daptomycin in 102 patients with infective endocarditis.
International journal of antimicrobial agents 2016 Jul;48;61-68 — 2016 Jul — 61-68
[Acute eosinophilic pneumonia secondary to daptomycin].
Enfermedades infecciosas y microbiologia clinica 2016 Jun-Jul;34;390-1 — 2016 Jun-Jul — 390-1
Dyspnea on daptomycin: eosinophilic pneumonia.
Rhode Island medical journal (2013) 2015 Jun 01;98;41-3 — 2015 Jun 01 — 41-3
Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection.
Surgical infections 2014 Dec;15;834-7 — 2014 Dec — 834-7
Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports.
Drug safety 2012 Jun 01;35;447-57 — 2012 Jun 01 — 447-57
A rare cause of pulmonary infiltrates one should be aware of: a case of daptomycin-induced acute eosinophilic pneumonia.
Infection 2011 Dec;39;583-5 — 2011 Dec — 583-5
Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature.
Journal of medical case reports 2011 Jan 17;5;13 — 2011 Jan 17 — 13
Eosinophilic pneumonia induced by daptomycin.
The Journal of infection 2007 Apr;54;e211-3 — 2007 Apr — e211-3