The Drug-Induced Respiratory Disease Website

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

G N, Chan M, Gue YX, Gorog DA

Fatal heart block from intentional yew tree () ingestion: a case report.

European heart journal. Case reports 2020 Feb;4;1-4 — 2020 Feb — 1-4

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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