The Drug-Induced Respiratory Disease Website

Dabrafenib-Trametinib combination (BRAFi)

Granulomatosis with polyangiitis (typically +ANCA). Or flare of preexisting GPA

Dimou A, Barron G, Merrick DT, Kolfenbach J, Doebele RC

Granulomatosis with polyangiitis in a patient treated with dabrafenib and trametinib for BRAF V600E positive lung adenocarcinoma.

BMC cancer 2020 Mar 04;20;177 — 2020 Mar 04 — 177

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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