The Drug-Induced Respiratory Disease Website

Palbociclib

Pneumonitis (ILD)

See Cruse A et al. A case of sacituzumab-induced pneumonitis. Chest 2023; 164 (45) 3316A

Mathew N, Joel A, Andrews AG, John AO, Singh A

CDK 4/6 inhibitor induced lung injury: a case report and review of literature.

Ecancermedicalscience 2021;15;1245 — 2021 — 1245

Nawa H, Niimura T, Yagi K, Goda M, Zamami Y, Ishizawa K

Evaluation of potential complication of interstitial lung disease with abemaciclib and palbociclib treatments.

Cancer reports (Hoboken, N.J.) 2021 May 03;;e1402 — 2021 May 03 — e1402

Felip E, Llobera L, Perez-Mañá C, Quintela D, Guasch I, Margelí M, Teruel I, Cirauqui B, Centeno C, Romeo M, Ballana E, Quiroga V

New Drugs, Old Toxicities: Pneumonitis Related to Palbociclib - A Case Report.

Breast care (Basel, Switzerland) 2020 Oct;15;548-552 — 2020 Oct — 548-552

Jazieh KA, Budd GT, Dalpiaz N, Abraham J

Can CDK4/6 inhibitors cause fatal lung injury?

Expert review of anticancer therapy 2019 11;19;917-919 — 2019 11 — 917-919

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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