The Drug-Induced Respiratory Disease Website

Amitriptyline

Path: Myocarditis

Kassim T, Mahfood Haddad T, Rakhra A, Kabach A, Qurie A, Selim M, Nayfeh AS, Aly A, Holmberg MJ

A Case of Amitriptyline-induced Myocarditis.

Cureus 2018 Jun 19;10;e2840 — 2018 Jun 19 — e2840

Ansari A, Maron BJ, Berntson DG

Drug-induced toxic myocarditis.

Texas Heart Institute journal 2003;30;76-9 — 2003 — 76-9

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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