The Drug-Induced Respiratory Disease Website

Hydroxychloroquine

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Arrhythmias-Dysrhythmias, including atrial fibrillation (Review at PMID 15582307), ventricular tachycardia/fibrillation See also under torsades de pointe under XIIt

Publications

Oscanoa TJ, Vidal X, Kanters JK, Romero-Ortuno R

Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: A Meta-analysis.

International journal of antimicrobial agents 2020 Dec;56;106212 — 2020 Dec — 106212

McBeth PB, Missirlis PI, Brar H, Dhingra V

Novel Therapies for Myocardial Irritability following Extreme Hydroxychloroquine Toxicity.

Case reports in emergency medicine 2015;2015;692948 — 2015 — 692948

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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