The Drug-Induced Respiratory Disease Website

Daptomycin

Rechallenge may not lead to relapse of the AE/ILD

Zimmer MA, Haffner E, Weisser CW, Mols G

[Daptomycin-induced eosinophilic pneumonia associated with an early endoprosthesis infection].

Der Anaesthesist 2020 Apr 08;; — 2020 Apr 08

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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