The Drug-Induced Respiratory Disease Website

Oxaliplatin

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

See under ‘oxaliplatin-based regimens‘ and ‘FOLFOX’.

Suthar KH, Al Mutar S, Venkatesan R

Oxaliplatin-induced Pulmonary Toxicity: A Rare but Serious Complication.

Cureus 2020 Mar 31;12;e7483 — 2020 Mar 31 — e7483

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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