The Drug-Induced Respiratory Disease Website
See PMID 29369189. (Fr: PnP a eosinophiles). See also under Ie (Acute eosinophilic pneumonia), Xa (DRESS), XVb and XIXc. DI PIE may manifest with fever, dyspnea and wheezes. Eosinophilia can be present in blood, BAL and/or tissue (XVb). Blood and BAL eosinophilia (XIXc) may suffice to secure the diagnosis without recourse to the lung biopsy. Imaging is similar to PIE of other causes. PIE can be part of the DRESS syndrome (Xa), a systemic illness with a cutaneous rash, hematologic abnormalities and deep-seated organ involvement. A few drugs may cause PIE and eosinophilic granulomatosis and polyangiitis (EGPA) formerly known as the Churg-Strauss syndrome) (Xh). Drugs causing eosinophilia at PMID 15062599, 30256812
Publications
From Medication to Complication: A Case Report of Acute Eosinophilic Pneumonia Associated With Naltrexone.
Clinical case reports 2025 Apr;13;e70372 — 2025 Apr — e70372
A case of naltrexone-induced acute eosinophilic pneumonia.
BMJ case reports 2024 May 02;17; — 2024 May 02
A Case for Biopsy: Injectable Naltrexone-Induced Acute Eosinophilic Pneumonia.
Cureus 2020 Sep 03;12;e10221 — 2020 Sep 03 — e10221