The Drug-Induced Respiratory Disease Website

Amiodarone

Multisystem/systemic inflammatory response/syndrome

May take the from of pseudosepsis

Kugasia IR, Ijaz M, Khan A, Jasti Y

Amiodarone Toxicity Presenting with Acute Onset of Systemic Inflammatory Response Syndrome and Multiorgan Failure Mimicking Sepsis.

The American journal of case reports 2020 Oct 23;21;e926929 — 2020 Oct 23 — e926929

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

No activity has been recorded yet.