The Drug-Induced Respiratory Disease Website

Sertraline

Pleural effusion and coexisting ILD (both drug-induced)

Lepore M, Campbell N

Sertraline as a rare cause of interstitial lung disease.

Oxford medical case reports 2021 Apr;2021;omab014 — 2021 Apr — omab014

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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