The Drug-Induced Respiratory Disease Website

Pregabalin

Generalized myopathy/muscle weakness

Or paralysis

Hegde V, Shekar N, Garrett F, Baz M, Anstead M

Pregabalin-Induced Myopathy in a Double Lung Transplant Recipient.

Cureus 2020 Dec 06;12;e11935 — 2020 Dec 06 — e11935

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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