The Drug-Induced Respiratory Disease Website

Bupropion

Tachycardia

Search for exposure to B2 agonists, theophylline, epinephrine, thyroid hormones, and abused substances/drugs recommended

Offerman S, Levine M, Gosen J, Thomas SH

Pediatric Bupropion Ingestions in Adolescents vs. Younger Children-a Tale of Two Populations.

Journal of medical toxicology : official journal of the American College of Medical Toxicology 2020 01;16;6-11 — 2020 01 — 6-11

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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