The Drug-Induced Respiratory Disease Website
Typically noncardiac. Includies chest tightness. See also under pill-induced esophageal pathologies under XIh, XIi, XIk and XIax that may cause substernal pain. Dedicated review at PMID 9403280. See also under Vi. Can be substernal, or in other areas of the chest. Can be acute, transfixiating and worrisome. Sometimes called 'acute chest syndrome'. Lung findings on imaging can be minimal. Depending on drug and patient, this may correspond to acute pleuritis or pleuro-pneumonitis, subpleural consolidation, GERD, pulmonary vasospasm, tracheal irritation, acute coronary syndrome or remain unexplained (PMID 30697107). See also under pleuritic chest pain (XIc), drug-induced lupus, pleuro-pulmonary lupus and acute coronary syndrome. Differential diagnosis on imaging at PMID 26373647
Publications
Acute Pericarditis Post mRNA-1273 COVID Vaccine Booster.
Cureus 2022 Feb;14;e22148 — 2022 Feb — e22148
A report of two cases of myocarditis following mRNA coronavirus disease 2019 vaccination.
European heart journal. Case reports 2022 Jan;6;ytac004 — 2022 Jan — ytac004
Larson KF, Ammirati E, Adler ED, Cooper LT, Hong KN, Saponara G, Couri D, Cereda A, Procopio A, Cavalotti C, Oliva F, Sanna T, Ciconte VA, Onyango G, Holmes DR, Borgeson DD
Myocarditis after BNT162b2 and mRNA-1273 Vaccination.
Circulation 2021 Jun 16;; — 2021 Jun 16