The Drug-Induced Respiratory Disease Website

Durvalumab

Myopathy-Myositis-Polymyositis

Including acute myositis, rhabdomyolysis, a mimic of autoimmune anti-Jo1-positive polymyositis/dermato-polymyositis and necrotizing autoimmune myopathy. Respiratory muscles can be involved (PMID 12904161): see specifically under IXac, Xba

Publications

Cham J, Ng D, Nicholson L

Durvalumab-induced myocarditis, myositis, and myasthenia gravis: a case report.

Journal of medical case reports 2021 May 31;15;278 — 2021 May 31 — 278

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

LATEST CHANGELOG

No activity has been recorded yet.

View full changelog