The Drug-Induced Respiratory Disease Website

Durvalumab

Myasthenia gravis - Myasthenic-like syndrome

May ccause ARF. See also under respiratory muscle weakness

Cham J, Ng D, Nicholson L

Durvalumab-induced myocarditis, myositis, and myasthenia gravis: a case report.

Journal of medical case reports 2021 May 31;15;278 — 2021 May 31 — 278

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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