The Drug-Induced Respiratory Disease Website

Tofacitinib

Nontuberculous pulmonary mycobacterial infection/superinfection

NTM, M bovis or other species

Gilvaz VJ, Mody E, Abaalkhail S

A Case of Disseminated Cutaneous Infection During Treatment With Tofacitinib.

The Journal of rheumatology 2021 Jul 01;; — 2021 Jul 01

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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