The Drug-Induced Respiratory Disease Website
May reverse with drug discontinuation. Generally similar to primary PHTn clinically, hemodynamically and on pathology. PMID 23997051. A few cases are thromboembolic in nature (PMID 24881082). Reviews at PMID 29508628, 30545968
Publications
Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report.
Medicine 2017 Jan;96;e4985 — 2017 Jan — e4985
Savale L, Chaumais MC, Cottin V, Bergot E, Frachon I, Prevot G, Pison C, Dromer C, Poubeau P, Lamblin N, Habib G, Reynaud-Gaubert M, Bourdin A, Sanchez O, Tubert-Bitter P, Jaïs X, Montani D, Sitbon O, Simonneau G, Humbert M
Pulmonary hypertension associated with benfluorex exposure.
The European respiratory journal 2012 Nov;40;1164-72 — 2012 Nov — 1164-72
Pulmonary arterial hypertension and benfluorex: 5 case reports.
Therapie 2011 Mar-Apr;66;135-8 — 2011 Mar-Apr — 135-8
Boutet K, Frachon I, Jobic Y, Gut-Gobert C, Leroyer C, Carlhant-Kowalski D, Sitbon O, Simonneau G, Humbert M
Fenfluramine-like cardiovascular side-effects of benfluorex.
The European respiratory journal 2009 Mar;33;684-8 — 2009 Mar — 684-8