The Drug-Induced Respiratory Disease Website

Remdesivir

Heart block (bundle branch- or AV-)

AV block may be complete and/or irreversible

Selvaraj V, Bavishi C, Patel S, Dapaah-Afriyie K

Complete heart block associated with Remdesivir in COVID-19: a case report.

European heart journal. Case reports 2021 Jul;5;ytab200 — 2021 Jul — ytab200

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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