The Drug-Induced Respiratory Disease Website

Coronavirus (SARS-COVID19) vaccination/vaccine

Takotsubo (stress) cardiomyopathy

Cases have also been described following drug overdose (PMID 25172356) or withdrawal (24170890)

Gräni C

Reply: Takotsubo Cardiomyopathy after Receiving mRNA COVID-19 Vaccination is Very Rare.

Heart, lung & circulation 2022 Feb 07;; — 2022 Feb 07

Boscolo Berto M, Spano G, Wagner B, Bernhard B, Häner J, Huber AT, Gräni C

Takotsubo Cardiomyopathy After mRNA COVID-19 Vaccination.

Heart, lung & circulation 2021 Jul 15;; — 2021 Jul 15

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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