Philippe Camus, M.D.

Dijon, France

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Pulmonary edema, noncardiogenic (NCPE)

(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO

Publications

García M, Albizua Madariaga I, Sainz-Gil M, Lertxundi U

Acetazolamide-induced pulmonary oedema: A disproportionality analysis from the EudraVigilance database.

British journal of clinical pharmacology 2024 Jul;90;1751-1755 — 2024 Jul — 1751-1755

Schwartz AH, Sieminski S

Acetazolamide induced noncardiogenic pulmonary edema, an underreported serious adverse event.

American journal of ophthalmology case reports 2023 Jun;30;101827 — 2023 Jun — 101827

Ono Y, Morifusa M, Ikeda S, Kunishige C, Tohma Y

A case of non-cardiogenic pulmonary edema provoked by intravenous acetazolamide.

Acute medicine & surgery 2017 Jul;4;349-352 — 2017 Jul — 349-352

Guven Yilmaz S, Palamar M, Gurgun C

Acute pulmonary oedema due to single dose acetazolamide taken after cataract surgery.

BMJ case reports 2016 May 11;2016; — 2016 May 11

Zimmermann S, Achenbach S, Wolf M, Janka R, Marwan M, Mahler V

Recurrent shock and pulmonary edema due to acetazolamide medication after cataract surgery.

Heart & lung : the journal of critical care 2014 Mar-Apr;43;124-6 — 2014 Mar-Apr — 124-6

Vogiatzis I, Koulouris E, Sidiropoulos A, Giannakoulas C

Acute pulmonary edema after a single oral dose of acetazolamide.

Hippokratia 2013 Apr;17;177-9 — 2013 Apr — 177-9

Gallerani M, Manzoli N, Fellin R, Simonato M, Orzincolo C

Anaphylactic shock and acute pulmonary edema after a single oral dose of acetazolamide.

The American journal of emergency medicine 2002 Jul;20;371-2 — 2002 Jul — 371-2