The Drug-Induced Respiratory Disease Website
Or 'ILD'. (Fr: PnP subaiguë). A.k.a. pulmonary infiltrates. Generally bilateral and symmetrical. Gradual onset. Consistent with but not specific for an NSIP-c pattern on pathology. Less- dense, severe, acute and diffuse than pattern Ia. Lacks the features of ARDS that may accompany pattern Ia. Can be in the form of disseminated linear, reticulonodular, miliary or patchy opacities. BAL is indicated to separate this pattern from PIE (Ic) or DAH (IIIa). Acute chest pain can be at the forefront. A search for microorganisms including Pneumocystis (stains, PCR) is indicated. On pathology (although not many cases undergo a confirmatory lung biopsy), there is interstitial inflammation and a more or less dense cellular interstitial cellular infiltrate (NSIP-c). Fibrosis, alveolar edema and/or a reactive epithelium denote those cases resulting from with antineoplastic chemotherapy agents. The frontier between patterns Ia and I b can be difficult to draw, so please check drugs under both Ia and Ib. Patients may quickly shift from pattern Ib to Ia particularly if the the causal drug is inappropriately continued. Prompt withdrawal must be considered, underlying disease permitting, and can be therapeutic.
Publications
Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review.
The Korean journal of internal medicine 2022 Aug 22;; — 2022 Aug 22
A case of interstitial lung disease following Oxford-AstraZeneca COVID-19 vaccination.
Internal medicine journal 2022 Jul;52;1276-1277 — 2022 Jul — 1276-1277
Acute Exacerbation of Idiopathic Pulmonary Fibrosis after SARS-CoV-2 Vaccination.
The European respiratory journal 2022 Feb 10;; — 2022 Feb 10
Delayed hypersensitivity to the Comirnaty coronavirus disease 2019 vaccine presenting with pneumonitis and rash.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2021 Nov 20;; — 2021 Nov 20
Shimizu T, Watanabe S, Yoneda T, Kinoshita M, Terada N, Kobayashi T, Gohara K, Tsuji T, Nakatsumi H, Tambo Y, Ohkura N, Abo M, Hara J, Sone T, Kimura H, Kasahara K
Interstitial pneumonitis after COVID-19 vaccination: A report of three cases.
Allergology international : official journal of the Japanese Society of Allergology 2021 Nov 09;; — 2021 Nov 09
COVID-19 vaccine-related interstitial lung disease: a case study.
Thorax 2021 Aug 06;; — 2021 Aug 06