The Drug-Induced Respiratory Disease Website

Antimigraine drug

Necrotizing eosinophilic myocarditis

Beck-da-Silva L, Maulaz A, Schvartzman P, Oliveira FH, Stifft J, Astigarraga C, Kronfeld M

Acute necrotizing eosinophilic myocarditis possibly triggered by an antimigraine drug as an uncommon cause of acute heart failure: a case report.

European heart journal. Case reports 2021 Aug;5;ytab286 — 2021 Aug — ytab286

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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