The Drug-Induced Respiratory Disease Website

Daptomycin

Imaging: An area or areas of consolidation

Watts A, Toquica Gahona CC, Raj K

Multifocal Pneumonia Amidst the Global COVID-19 Pandemic: A Case of Daptomycin-Induced Eosinophilic Pneumonia.

Cureus 2021 Jun;13;e16002 — 2021 Jun — e16002

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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