The Drug-Induced Respiratory Disease Website
(Fr: OAP non cardiogénique). A.k.a. permeability edema. Typically acute and florid. Less often subaute/benign. PE often omplicates drug overdoses, particularly when given I.V. May accompany anaphylactic shock (PMID 29086053). May cause the ARDS picture. Drug-induced pulmonary edema cases generally have an acute or sudden onset, and are noncardiac (normal heart US and wedge pressure when measured) (NCPE). Transient fleeting pulmonary infiltrates were often reported as 'acute allergic pulmonary edema'. Hyperacute PE cases are sometimes called 'flash pulmonary edema' (see under IIi). Severe NCPE cases may exhibit the characteristic of ARDS (PMID 3532567, 15062601, 7555128, 1914570). The diagnosis of NCPE is raised when timing of the reaction is shortly (seconds to minutes) following administration of the causal drug or agent. NCPE is also a feature of anaphylaxis episodes (PMID 24376328). Patients with pulmonary hypertension are prone to the development of vasoldilator-induced NCPE (see under NO and other pulmonary vasodilator drugs). NCPE will generally relapse if the patient is reexposed to the drug. Note: overzealous administration of i.v. fluids or blood to a patient whose cardiocirculatory system cannot accomodate it may cause overload (hydrostatic) pulmonary edema (IIh) or TACO
Publications
Atosiban-induced acute pulmonary edema: A rare but severe complication of tocolysis.
Heliyon 2023 May;9;e15829 — 2023 May — e15829
A case of severe non-cardiogenic pulmonary edema in a woman treated with atosiban for preterm labor.
European review for medical and pharmacological sciences 2023 Feb;27;1305-1310 — 2023 Feb — 1305-1310
The combination of corticosteroid and tocolytic therapy in a preeclamptic patient is a risk factor for the development of acute pulmonary oedema.
International journal of obstetric anesthesia 2018 05;34;113-114 — 2018 05 — 113-114
Non-cardiogenic pulmonary edema in a woman treated with atosiban for preterm labor.
European journal of obstetrics, gynecology, and reproductive biology 2017 12;219;132-133 — 2017 12 — 132-133
Severe non-cardiogenic pulmonary oedema secondary to atosiban and steroids.
International journal of obstetric anesthesia 2011 Apr;20;189-90 — 2011 Apr — 189-90
Non-cardiogenic lung edema in a woman treated with atosiban for preterm labor.
Journal of perinatal medicine 2008;36;455-7 — 2008 — 455-7