The Drug-Induced Respiratory Disease Website

Tofacitinib

Pneumonitis (ILD)

Incidence rates for ILD in RA patients receiving tofacitinib statistically similar to controls (placebo-exposed) PMID « É!É§§(È

Verstockt B, Pouillon L, Bossuyt P

Tofacitinib and Subacute Pneumonitis: Don't Hold Your Breath.

Journal of Crohn's & colitis 2021 Apr 06;15;692-693 — 2021 Apr 06 — 692-693

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

LATEST CHANGELOG

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