The Drug-Induced Respiratory Disease Website
Typically noncardiac. Includies chest tightness. See also under pill-induced esophageal pathologies under XIh, XIi, XIk and XIax that may cause substernal pain. Dedicated review at PMID 9403280. See also under Vi. Can be substernal, or in other areas of the chest. Can be acute, transfixiating and worrisome. Sometimes called 'acute chest syndrome'. Lung findings on imaging can be minimal. Depending on drug and patient, this may correspond to acute pleuritis or pleuro-pneumonitis, subpleural consolidation, GERD, pulmonary vasospasm, tracheal irritation, acute coronary syndrome or remain unexplained (PMID 30697107). See also under pleuritic chest pain (XIc), drug-induced lupus, pleuro-pulmonary lupus and acute coronary syndrome. Differential diagnosis on imaging at PMID 26373647
Publications
Chest pain in a 12-year-old girl with ulcerative colitis after therapy with mesalazine.
BMJ case reports 2013 Jun 12;2013; — 2013 Jun 12
Mesalamine-induced myocarditis and coronary vasculitis in a pediatric ulcerative colitis patient: a case report.
Case reports in pediatrics 2011;2011;524364 — 2011 — 524364
Severe chest pain in a pediatric ulcerative colitis patient after 5-aminosalicylic acid therapy.
World journal of gastroenterology 2008 Jul 21;14;4400-2 — 2008 Jul 21 — 4400-2
Mesalamine-induced chest pain: a case report.
The Canadian journal of cardiology 2000 May;16;667-9 — 2000 May — 667-9