The Drug-Induced Respiratory Disease Website

Perampanel

Bradycardia

Winkler GA, Minns AB, Kreshak AA

Severe Perampanel Toxicity in a Pediatric Patient With Prolonged Symptoms.

The Journal of emergency medicine 2021 Aug 31;; — 2021 Aug 31

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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