The Drug-Induced Respiratory Disease Website

Osimertinib

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Arrhythmias-Dysrhythmias, including atrial fibrillation (Review at PMID 15582307), ventricular tachycardia/fibrillation See also under torsades de pointe under XIIt

Publications

Guo GG, Luo X, Zhu K, Li LL, Ou YF

Fatal ventricular arrhythmias after osimertinib treatment for lung adenocarcinoma: a case report.

Journal of geriatric cardiology : JGC 2023 Mar 28;20;242-246 — 2023 Mar 28 — 242-246

Ikebe S, Amiya R, Minami S, Ihara S, Higuchi Y, Komuta K

Osimertinib-induced cardiac failure with QT prolongation and torsade de pointes in a patient with advanced pulmonary adenocarcinoma.

International cancer conference journal 2021 Jan;10;68-71 — 2021 Jan — 68-71

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

Diagnosing DIRD

Identify causative drugs

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