The Drug-Induced Respiratory Disease Website
See also PMIDs 31612562, 34359324. Several drugs can cause a mimic of naturally-occurring endo- and/or extra-thoracic sarcoid-like reaction/sarcoidosis, or a flare of previously diagnosed sarcoidosis (particularly with the use of interferon, anti-TNF agents, or immune checkpoint inhibitors (PMID: 27504482). Both the timing of exposure to the drug and the effect of discontinuation are important to evaluate whether the condition is drug-related. Examination of the skin including scars and/or tatoo edges for evidence of granuloma can be rewarding (PMIDs 24239377, 33905479, 34359324). See also under VIIa, VIIe, Xl.
Publications
Successful immunosuppressant-free treatment of a drug-induced sarcoidosis-like reaction caused by dupilumab.
Respiratory medicine case reports 2023;44;101883 — 2023 — 101883
Belhomme N, Gaignon T, Jouneau S, Misery L, Abasq-Thomas C, Cador B, Lecureur V, Cadiou S, Ballerie A, Polard E, Mensi S, Jego P, Lescoat A
Drug-induced granulomatosis: is dupilumab the new kid on the block?
Journal of the European Academy of Dermatology and Venereology : JEADV 2020 Jul;34;e312-e313 — 2020 Jul — e312-e313