The Drug-Induced Respiratory Disease Website

Chlorine gas (dichlorine: Cl2)

Tracheal injury

Zou RH, Tiberio PJ, Micciche AF, Yanta JH, Rose JJ

A Woman with Respiratory Failure from Cleaning Product Misuse.

Annals of the American Thoracic Society 2021 01;18;162-166 — 2021 01 — 162-166

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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