The Drug-Induced Respiratory Disease Website

Hydralazine

Occupational asthma

Useful resources: PMID 23706060, 26203621, 28942932, 30075340

http://www.csst.qc.ca/en/prevention/reptox/occupational-asthma/

http://www.eaaci.org/images/pdf.files/Occupational_Allergens_1-16.pdf

http://www.eaaci.org/images/pdf.files/occupational%20allergens%201-14.pdf

Perrin B, Malo JL, Cartier A, Evans S, Dolovich J

Occupational asthma in a pharmaceutical worker exposed to hydralazine.

Thorax 1990 Dec;45;980-1 — 1990 Dec — 980-1

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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