The Drug-Induced Respiratory Disease Website

Immune checkpoint inhibitors (ICI) - ICI combinatorial Rx

Pulmonary embolism - Venous thrombosis/thrombo-embolism

See PMID 34858058

Kunimasa K, Nishino K, Kimura M, Inoue T, Tamiya M, Kumagai T, Imamura F

Pembrolizumab-induced acute thrombosis: A case report.

Medicine 2018 May;97;e10772 — 2018 May — e10772

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

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